Structural basis for heme detoxification by an ATP-binding cassette–type efflux pump in gram-positive pathogenic bacteria

Bacterial pathogens acquire heme from the host hemoglobin as an iron nutrient for their virulence and proliferation in blood. Concurrently, they encounter cytotoxic-free heme that escapes the heme-acquisition process. To overcome this toxicity, many gram-positive bacteria employ an ATP-binding casse...

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Detalles Bibliográficos
Autores principales: Nakamura, Hiro, Hisano, Tamao, Rahman, Md. Mahfuzur, Tosha, Takehiko, Shirouzu, Mikako, Shiro, Yoshitsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271180/
https://www.ncbi.nlm.nih.gov/pubmed/35767641
http://dx.doi.org/10.1073/pnas.2123385119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271180/
https://www.ncbi.nlm.nih.gov/pubmed/35767641
http://dx.doi.org/10.1073/pnas.2123385119

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