Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and are derived from ancient integrations of retroviruses into the germline. The biology of HERVs is poorly defined, but there is accumulating evidence supporting pathological roles in diverse diseases, such as cancer, auto...

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Detalles Bibliográficos
Autores principales: Baldwin, Eric T., Götte, Matthias, Tchesnokov, Egor P., Arnold, Eddy, Hagel, Margit, Nichols, Charles, Dossang, Pam, Lamers, Marieke, Wan, Paul, Steinbacher, Stefan, Romero, Donna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271190/
https://www.ncbi.nlm.nih.gov/pubmed/35771941
http://dx.doi.org/10.1073/pnas.2200260119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271190/
https://www.ncbi.nlm.nih.gov/pubmed/35771941
http://dx.doi.org/10.1073/pnas.2200260119

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