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Early expression of mature αβ TCR in CD4(−)CD8(−) T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations
During normal T cell development in mouse and human, a low-frequency population of immature CD4(−)CD8(−) double-negative (DN) thymocytes expresses early, mature αβ T cell antigen receptor (TCR). We report that these early αβ TCR+ DN (EADN) cells are DN3b-DN4 stage and require CD3δ but not major hist...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271211/ https://www.ncbi.nlm.nih.gov/pubmed/35767640 http://dx.doi.org/10.1073/pnas.2118529119 |