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Early expression of mature αβ TCR in CD4(−)CD8(−) T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations

During normal T cell development in mouse and human, a low-frequency population of immature CD4(−)CD8(−) double-negative (DN) thymocytes expresses early, mature αβ T cell antigen receptor (TCR). We report that these early αβ TCR+ DN (EADN) cells are DN3b-DN4 stage and require CD3δ but not major hist...

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Detalles Bibliográficos
Autores principales:	Laffey, Kimberly G., Stiles, Robert J., Ludescher, Melissa J., Davis, Tessa R., Khwaja, Shariq S., Bram, Richard J., Wettstein, Peter J., Ramachandran, Venkataraman, Parks, Christopher A., Reyes, Edwin E., Ferrer, Alejandro, Canfield, Jenna M., Johnson, Cory E., Hammer, Richard D., Gil, Diana, Schrum, Adam G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271211/ https://www.ncbi.nlm.nih.gov/pubmed/35767640 http://dx.doi.org/10.1073/pnas.2118529119

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