Cargando…

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

Coumarin and chalcone, two important kinds of natural product skeletons, both exhibit α-glucosidase inhibitory activity. In this work, coumarin-chalcone derivatives 3 (a∼v) were synthesized, and their α-glucosidase inhibitory activity was screened. The results showed that all synthetic derivatives (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Chun-Mei, Luo, Yong-Xin, Wang, Wen-Jing, Li, Jian-Ping, Li, Meng-Yue, Zhang, Yu-Fei, Xiao, Di, Lu, Li, Xiong, Zhuang, Feng, Na, Li, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271751/ https://www.ncbi.nlm.nih.gov/pubmed/35832461 http://dx.doi.org/10.3389/fchem.2022.926543

Ejemplares similares

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors
por: Lin, Jing, et al.
Publicado: (2022)

Responsive Fluorescent Coumarin–Cinnamic Acid Conjugates for α-Glucosidase Detection
por: Luo, Dong, et al.
Publicado: (2022)

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
por: Tariq, Hafiza Zara, et al.
Publicado: (2023)

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

A Review of the In Vitro Inhibition of α-Amylase and α-Glucosidase by Chalcone Derivatives
por: Tran, Thanh-Dao, et al.
Publicado: (2023)

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
por: Deng, Xu-Yang, et al.
Publicado: (2022)

Synthesis of activity evaluation of flavonoid derivatives as ɑ-glucosidase inhibitors
por: Zhu, Hua, et al.
Publicado: (2022)

Chemical synthesis, inhibitory activity and molecular mechanism of 1-deoxynojirimycin–chrysin as a potent α-glucosidase inhibitor
por: Zhang, Ran, et al.
Publicado: (2021)

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Synthesis, in vitro biological assessment, and molecular docking study of benzimidazole-based thiadiazole derivatives as dual inhibitors of α-amylase and α-glucosidase
por: Khan, Shoaib, et al.
Publicado: (2023)

N (α)-arylsulfonyl histamines as selective β-glucosidase inhibitors
por: Salazar, M. O., et al.
Publicado: (2018)

Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies
por: Moya-Alvarado, Guillermo, et al.
Publicado: (2021)

QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors
por: Xu, Jun, et al.
Publicado: (2010)

New chalcone derivatives: synthesis, antiviral activity and mechanism of action
por: Fu, Yun, et al.
Publicado: (2020)

α-Glucosidase Inhibitors From the Coral-Associated Fungus Aspergillus terreus
por: Liu, Mengting, et al.
Publicado: (2018)

Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors
por: Ajaz, Aliya, et al.
Publicado: (2023)

Triterpenoids with α-glucosidase inhibitory activity and cytotoxic activity from the leaves of Akebia trifoliata
por: Ouyang, Jin-Kui, et al.
Publicado: (2018)

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids
por: Otero, Elver, et al.
Publicado: (2014)

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents
por: Niri, Davood Rezapour, et al.
Publicado: (2022)

Synthesis and application of coumarin fluorescence probes
por: Sun, Xiao-ya, et al.
Publicado: (2020)

Correction: Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors
por: Ajaz, Aliya, et al.
Publicado: (2023)

Synthesis of amantadine clubbed N-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies
por: Zahra, Fatima Tuz, et al.
Publicado: (2023)

A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
por: Du, Li-Hua, et al.
Publicado: (2020)

Aspulvinones Suppress Postprandial Hyperglycemia as Potent α-Glucosidase Inhibitors From Aspergillus terreus ASM-1
por: Wu, Changjing, et al.
Publicado: (2021)

Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors
por: Fu, Zhe, et al.
Publicado: (2022)

Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents
por: Alhakamy, Nabil A., et al.
Publicado: (2023)

Chemoselective and one-pot synthesis of novel coumarin-based cyclopenta[c]pyrans via base-mediated reaction of α,β-unsaturated coumarins and β-ketodinitriles
por: Farajpour, Behnaz, et al.
Publicado: (2022)

Synthesis and evaluation of new chalcones and oximes as anticancer agents
por: Bukhari, Syed Nasir Abbas
Publicado: (2022)

Design and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
por: Mobinikhaledi, Akbar, et al.
Publicado: (2015)

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
por: Liu, Shan-Kui, et al.
Publicado: (2021)

Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family
por: Ishikawa, Fumihiro, et al.
Publicado: (2021)

Design, synthesis, in silico, and in vitro evaluation of benzylbenzimidazolone derivatives as potential drugs on α-glucosidase and glucokinase as pharmacological targets
por: Santos-Ballardo, Cress Lumadhar, et al.
Publicado: (2023)

Design, Synthesis, and Biological Activity of Novel Chalcone Derivatives Containing an 1,2,4-Oxadiazole Moiety
por: Luo, Ling, et al.
Publicado: (2022)

Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate
por: Guo, Tao, et al.
Publicado: (2019)

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents
por: Garcia, Andreza R., et al.
Publicado: (2021)

Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
por: Alshabanah, Latifah A., et al.
Publicado: (2022)

Correction: Chemoselective and one-pot synthesis of novel coumarin-based cyclopenta[c]pyrans via base-mediated reaction of α,β-unsaturated coumarins and β-ketodinitriles
por: Farajpour, Behnaz, et al.
Publicado: (2022)

Design, Synthesis, and Activity Evaluation of Novel N-benzyl Deoxynojirimycin Derivatives for Use as α-Glucosidase Inhibitors
por: Zeng, Fanxin, et al.
Publicado: (2019)

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors
por: Zheng, Peng-Fei, et al.
Publicado: (2021)

Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches
por: Patil, Shashank M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_58mleiv6qfjpab878hhajvvqcs