Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4-2) is an epilepsy-associated gene encoding an E3 ligase that ubiquitinates neuroactive substrates. An involvement of NEDD4-2 in endoplasmic reticulum (ER) stress has been recently found with mechanisms needing further i...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoliang, Zhang, Lu, Zhang, Hebo, Liang, Xiaoyan, Zhang, Bijun, Tu, Jianqiao, Zhao, Yanyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271913/
https://www.ncbi.nlm.nih.gov/pubmed/35832397
http://dx.doi.org/10.3389/fnmol.2022.919718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271913/
https://www.ncbi.nlm.nih.gov/pubmed/35832397
http://dx.doi.org/10.3389/fnmol.2022.919718

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