Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

Cooling at 4°C is routinely used to lower metabolism and preserve cell and tissue integrity in laboratory and clinical settings, including organ transplantation. However, cooling and rewarming produce cell damage, attributed primarily to a burst of reactive oxygen species (ROS) upon rewarming. While...

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Detalles Bibliográficos
Autores principales: Tolouee, Marziyeh, Hendriks, Koen D. W., Lie, Fia Fia, Gartzke, Lucas P., Goris, Maaike, Hoogstra-Berends, Femke, Bergink, Steven, Henning, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272479/
https://www.ncbi.nlm.nih.gov/pubmed/35808831
http://dx.doi.org/10.1177/09636897221108705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272479/
https://www.ncbi.nlm.nih.gov/pubmed/35808831
http://dx.doi.org/10.1177/09636897221108705

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