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Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion
Cooling at 4°C is routinely used to lower metabolism and preserve cell and tissue integrity in laboratory and clinical settings, including organ transplantation. However, cooling and rewarming produce cell damage, attributed primarily to a burst of reactive oxygen species (ROS) upon rewarming. While...
Autores principales: | Tolouee, Marziyeh, Hendriks, Koen D. W., Lie, Fia Fia, Gartzke, Lucas P., Goris, Maaike, Hoogstra-Berends, Femke, Bergink, Steven, Henning, Robert H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272479/ https://www.ncbi.nlm.nih.gov/pubmed/35808831 http://dx.doi.org/10.1177/09636897221108705 |
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