Lopinavir-menthol co-crystals for enhanced dissolution rate and intestinal absorption

Lopinavir is an antiretroviral, antiparasitic agent and recently utilized in treatment of COVID-19. Unfortunately, lopinavir exhibited poor oral bioavailability due to poor dissolution, extensive pre-systemic metabolism, and significant P-glycoprotein intestinal efflux. Accordingly, the aim was to e...

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Detalles Bibliográficos
Autores principales: Fayed, Noha D., Arafa, Mona F., Essa, Ebtesam A., El Maghraby, Gamal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272570/
https://www.ncbi.nlm.nih.gov/pubmed/35845293
http://dx.doi.org/10.1016/j.jddst.2022.103587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272570/
https://www.ncbi.nlm.nih.gov/pubmed/35845293
http://dx.doi.org/10.1016/j.jddst.2022.103587

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