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gcFront: a tool for determining a Pareto front of growth-coupled cell factory designs
MOTIVATION: A widely applicable strategy to create cell factories is to knockout (KO) genes or reactions to redirect cell metabolism so that chemical synthesis is made obligatory when the cell grows at its maximum rate. Synthesis is thus growth-coupled, and the stronger the coupling the more deleter...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272801/ https://www.ncbi.nlm.nih.gov/pubmed/35642935 http://dx.doi.org/10.1093/bioinformatics/btac376 |