gcFront: a tool for determining a Pareto front of growth-coupled cell factory designs

MOTIVATION: A widely applicable strategy to create cell factories is to knockout (KO) genes or reactions to redirect cell metabolism so that chemical synthesis is made obligatory when the cell grows at its maximum rate. Synthesis is thus growth-coupled, and the stronger the coupling the more deleter...

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Detalles Bibliográficos
Autores principales: Legon, Laurence, Corre, Christophe, Bates, Declan G, Mannan, Ahmad A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272801/
https://www.ncbi.nlm.nih.gov/pubmed/35642935
http://dx.doi.org/10.1093/bioinformatics/btac376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272801/
https://www.ncbi.nlm.nih.gov/pubmed/35642935
http://dx.doi.org/10.1093/bioinformatics/btac376

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