Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids with potential activity against VEGFR-2. The cytotoxic effects of the synthesised derivatives against Caco-2, HepG-2, and MDA-MB-231 c...

Descripción completa

Detalles Bibliográficos
Autores principales: Taghour, Mohammed S., Elkady, Hazem, Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., Elkaeed, Eslam B., Alsfouk, Aisha A., Alesawy, Mohamed S., Metwaly, Ahmed M., Eissa, Ibrahim. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272924/
https://www.ncbi.nlm.nih.gov/pubmed/35801403
http://dx.doi.org/10.1080/14756366.2022.2085693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272924/
https://www.ncbi.nlm.nih.gov/pubmed/35801403
http://dx.doi.org/10.1080/14756366.2022.2085693

Ejemplares similares