Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting randomly-arranged sarbecovirus spike receptor-binding domains (RBDs) to elicit antibodies against epitopes that are conserved and...

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Detalles Bibliográficos
Autores principales: Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N. P., Kakutani, Leesa M., West, Anthony P., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273039/
https://www.ncbi.nlm.nih.gov/pubmed/35857620
http://dx.doi.org/10.1126/science.abq0839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273039/
https://www.ncbi.nlm.nih.gov/pubmed/35857620
http://dx.doi.org/10.1126/science.abq0839

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