Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice

Protamines are unique sperm-specific proteins that package and protect paternal chromatin until fertilization. A subset of mammalian species expresses two protamines (PRM1 and PRM2), while in others PRM1 is sufficient for sperm chromatin packaging. Alterations of the species-specific ratio between P...

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Detalles Bibliográficos
Autores principales: Arévalo, Lena, Merges, Gina Esther, Schneider, Simon, Oben, Franka Enow, Neumann, Isabelle Sophie, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273070/
https://www.ncbi.nlm.nih.gov/pubmed/35763544
http://dx.doi.org/10.1371/journal.pgen.1010272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273070/
https://www.ncbi.nlm.nih.gov/pubmed/35763544
http://dx.doi.org/10.1371/journal.pgen.1010272

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