Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) was described. Further, new formyl (5a,d-f) and nitro (9a,d-f) coumarin derivatives were synthesized via C-N coupling reaction of various cyclic second...

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Detalles Bibliográficos
Autores principales: Eliwa, Essam M., Frese, Marcel, Halawa, Ahmed H., Soltan, Maha M., Ponomareva, Larissa V., Thorson, Jon S., Shaaban, Khaled A., Shaaban, Mohamed, El-Agrody, Ahmed M., Sewald, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273165/
https://www.ncbi.nlm.nih.gov/pubmed/35821884
http://dx.doi.org/10.1080/17518253.2021.1981462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273165/
https://www.ncbi.nlm.nih.gov/pubmed/35821884
http://dx.doi.org/10.1080/17518253.2021.1981462

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