Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia

Familial dysautonomia (FD) is a sensory and autonomic neuropathy caused by mutations in elongator complex protein 1 (ELP1). FD patients have small trigeminal nerves and impaired facial pain and temperature perception. These signals are relayed by nociceptive neurons in the trigeminal ganglion, a str...

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Detalles Bibliográficos
Autores principales: Leonard, Carrie E, Quiros, Jolie, Lefcort, Frances, Taneyhill, Lisa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273214/
https://www.ncbi.nlm.nih.gov/pubmed/35713404
http://dx.doi.org/10.7554/eLife.71455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273214/
https://www.ncbi.nlm.nih.gov/pubmed/35713404
http://dx.doi.org/10.7554/eLife.71455

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