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Determinants of trafficking, conduction, and disease within a K(+) channel revealed through multiparametric deep mutational scanning
A long-standing goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships to understand how mutations cause disease. Deep mutational scanning (DMS) is a promising strategy to map how amino acids contribute to protein structure...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273215/ https://www.ncbi.nlm.nih.gov/pubmed/35639599 http://dx.doi.org/10.7554/eLife.76903 |