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Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β-Induced Oxygen Stress and Apoptosis but Promoted Proliferation and Autophagy via AMPK/m-TOR Pathway

OBJECTIVE: To investigate the protective effects of crocetin against transforming growth factor-β (TGF-β)—induced injury in LO2 cells. METHODS: Human hepatocyte LO2 cells were pre-treated with crocetin (10 μM) for 6, 12, and 24 h, and then induced by TGF-β. Proliferation, oxidative stress, apoptosis...

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Detalles Bibliográficos
Autores principales: Guo, Hongxing, Ruan, Chenyu, Zhan, Xiuhong, Pan, Hao, Luo, Yumei, Gao, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273739/
https://www.ncbi.nlm.nih.gov/pubmed/35836988
http://dx.doi.org/10.3389/fpubh.2022.909125