Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation

α-Synuclein is a 140 amino-acid intrinsically disordered protein mainly found in the brain. Toxic α-synuclein aggregates are the molecular hallmarks of Parkinson’s disease. In vitro studies showed that α-synuclein aggregates in oligomeric structures of several 10th of monomers and into cylindrical s...

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Detalles Bibliográficos
Autores principales: Guzzo , Adrien, Delarue , Patrice, Rojas, Ana, Nicolaï , Adrien, Maisuradze , Gia G., Senet, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273784/
https://www.ncbi.nlm.nih.gov/pubmed/35836937
http://dx.doi.org/10.3389/fmolb.2022.910104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273784/
https://www.ncbi.nlm.nih.gov/pubmed/35836937
http://dx.doi.org/10.3389/fmolb.2022.910104

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