Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough

BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and ovarian cancer. These mutations generate prem...

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Detalles Bibliográficos
Autores principales: Abreu, Renata B. V., Gomes, Thiago T., Nepomuceno, Thales C., Li, Xueli, Fuchshuber-Moraes, Mateus, De Gregoriis, Giuliana, Suarez-Kurtz, Guilherme, Monteiro, Alvaro N. A., Carvalho, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273842/
https://www.ncbi.nlm.nih.gov/pubmed/35837282
http://dx.doi.org/10.3389/fphar.2022.935995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273842/
https://www.ncbi.nlm.nih.gov/pubmed/35837282
http://dx.doi.org/10.3389/fphar.2022.935995

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