Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1

Creatine serves as an ATP buffer and is thus an integral component of cellular energy metabolism. Most cells maintain their creatine levels via uptake by the creatine transporter (CRT-1, SLC6A8). The activity of CRT-1, therefore, is a major determinant of cytosolic creatine concentrations. We determ...

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Detalles Bibliográficos
Autores principales: Farr, Clemens V., El-Kasaby, Ali, Erdem, Fatma A., Sucic, Sonja, Freissmuth, Michael, Sandtner, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273935/
https://www.ncbi.nlm.nih.gov/pubmed/35837012
http://dx.doi.org/10.3389/fphys.2022.919439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9273935/
https://www.ncbi.nlm.nih.gov/pubmed/35837012
http://dx.doi.org/10.3389/fphys.2022.919439

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