Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes

In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca(2+) homeostasis. Connexin36 (Cx36) gap junctions electrically couple β-cells to coordinate glucose-stimulated Ca(2+) and insulin secretion. Cx36 gap junction co...

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Detalles Bibliográficos
Autores principales: Farnsworth, Nikki L., Piscopio, Robert A., Schleicher, Wolfgang E., Ramirez, David G., Miranda, Jose G., Benninger, Richard K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274093/
https://www.ncbi.nlm.nih.gov/pubmed/35837011
http://dx.doi.org/10.3389/fphys.2022.913611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274093/
https://www.ncbi.nlm.nih.gov/pubmed/35837011
http://dx.doi.org/10.3389/fphys.2022.913611

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