Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney

The molecular and cellular pathogenesis of leptospirosis remains poorly understood. Based on comparative bacterial genomics data, we recently identified the hypothetical PF07598 gene family as encoding secreted exotoxins (VM proteins) that mediate cytotoxicity in vitro. To address whether VM protein...

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Detalles Bibliográficos
Autores principales: Chaurasia, Reetika, Salovey, Aryeh, Guo, Xiaojia, Desir, Gary, Vinetz, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274288/
https://www.ncbi.nlm.nih.gov/pubmed/35837473
http://dx.doi.org/10.3389/fcimb.2022.926994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274288/
https://www.ncbi.nlm.nih.gov/pubmed/35837473
http://dx.doi.org/10.3389/fcimb.2022.926994

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