Cargando…

Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their sequence homology and functional overlap and co-operation, are emerging as critical drivers of oncogenesis in the past several years. CBP/p300 induces histone H3 lysine 27 acetylation (H3K27ac) at target gene pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qingjuan, Yang, Binhui, Liu, Xiaochen, Zhang, Xu D., Zhang, Lirong, Liu, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274749/ https://www.ncbi.nlm.nih.gov/pubmed/35836809 http://dx.doi.org/10.7150/thno.73223

Ejemplares similares

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts
por: Chen, Guozhen, et al.
Publicado: (2009)

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
por: Michaelides, Michael R., et al.
Publicado: (2017)

Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP
por: Tang, Yong, et al.
Publicado: (2008)

MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300
por: Liu, Xiaoguang, et al.
Publicado: (2017)

Epigenetic mechanisms to propagate histone acetylation by p300/CBP
por: Kikuchi, Masaki, et al.
Publicado: (2023)

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders
por: Valor, Luis M, et al.
Publicado: (2013)

Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
por: Wright, Diana G, et al.
Publicado: (2014)

Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2015)

Is histone acetylation the most important physiological function for CBP and p300?
por: Bedford, David C., et al.
Publicado: (2012)

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300
por: Wolf, Louise, et al.
Publicado: (2013)

CBP and p300 Histone Acetyltransferases Contribute to Homologous Recombination by Transcriptionally Activating the BRCA1 and RAD51 Genes
por: Ogiwara, Hideaki, et al.
Publicado: (2012)

CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
por: Sauer, M, et al.
Publicado: (2017)

The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans
por: Barrett, Lindsey N., et al.
Publicado: (2022)

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity
por: Shirakawa, Kotaro, et al.
Publicado: (2016)

CBP / p300-mediated acetylation of histone H3 on lysine 56
por: Das, Chandrima, et al.
Publicado: (2009)

Curcumin, COX-2, and Protein p300/CBP
por: Jung, Ki Tae, et al.
Publicado: (2014)

Dimeric structure of p300/CBP associated factor
por: Shi, Shasha, et al.
Publicado: (2014)

Correction to Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2016)

New Inhibitors of the Human p300/CBP Acetyltransferase Are Selectively Active against the Arabidopsis HAC Proteins
por: Longo, Chiara, et al.
Publicado: (2022)

Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT
por: Liu, Yifan, et al.
Publicado: (2020)

Genomic occupancy of the transcriptional co-activators p300 and CBP
por: Holmqvist, Per-Henrik, et al.
Publicado: (2013)

Acetyltransferase p300/CBP Associated Factor (PCAF) Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition
por: Kornacki, James R., et al.
Publicado: (2014)

DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers
por: Li, Shanshan, et al.
Publicado: (2018)

CBP/p300 and SIRT1 Are Involved in Transcriptional Regulation of S-Phase Specific Histone Genes
por: He, Hongpeng, et al.
Publicado: (2011)

HBZ inhibits the HAT activity of the cellular coactivators p300 and CBP
por: Wright, Diana, et al.
Publicado: (2011)

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
por: Hay, Duncan A., et al.
Publicado: (2014)

The prognostic capacities of CBP and p300 in locally advanced rectal cancer
por: Rühlmann, Felix, et al.
Publicado: (2019)

Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
por: Lazar, Alexandra-Gela, et al.
Publicado: (2021)

Lysine Acetyltransferase p300/CBP Plays an Important Role in Reproduction, Embryogenesis and Longevity of the Pea Aphid Acyrthosiphon pisum
por: Kirfel, Phillipp, et al.
Publicado: (2020)

Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model
por: Zhu, Xiaoyan, et al.
Publicado: (2014)

Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP
por: Ghezzi, Alfredo, et al.
Publicado: (2017)

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation
por: Ramos, Yolande F. M., et al.
Publicado: (2010)

Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells
por: Bordonaro, Michael, et al.
Publicado: (2016)

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs
por: Martire, Sara, et al.
Publicado: (2020)

Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation
por: Hlushchuk, Irena, et al.
Publicado: (2021)

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma
por: Zhang, Xin, et al.
Publicado: (2020)

Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes
por: Narita, Takeo, et al.
Publicado: (2023)

CBP/p300 Bromodomain Inhibitor–I–CBP112 Declines Transcription of the Key ABC Transporters and Sensitizes Cancer Cells to Chemotherapy Drugs
por: Strachowska, Magdalena, et al.
Publicado: (2021)

Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice
por: Creighton, Samantha D., et al.
Publicado: (2022)

TGFβ Impairs HNF1α Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP/p300 Acetyltransferases
por: Bisceglia, Francesca, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dloee0i9aonvv6tkq4n2sp7vet