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Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning

A major challenge to the characterization of intrinsically disordered regions (IDRs), which are widespread in the proteome, but relatively poorly understood, is the identification of molecular features that mediate functions of these regions, such as short motifs, amino acid repeats and physicochemi...

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Detalles Bibliográficos
Autores principales: Lu, Alex X., Lu, Amy X., Pritišanac, Iva, Zarin, Taraneh, Forman-Kay, Julie D., Moses, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275697/
https://www.ncbi.nlm.nih.gov/pubmed/35767567
http://dx.doi.org/10.1371/journal.pcbi.1010238