BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models

KCNMA1 forms the pore of BK K(+) channels, which regulate neuronal and muscle excitability. Recently, genetic screening identified heterozygous KCNMA1 variants in a subset of patients with debilitating paroxysmal non-kinesigenic dyskinesia, presenting with or without epilepsy (PNKD3). However, the r...

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Detalles Bibliográficos
Autores principales: Park, Su Mi, Roache, Cooper E, Iffland, Philip H, Moldenhauer, Hans J, Matychak, Katia K, Plante, Amber E, Lieberman, Abby G, Crino, Peter B, Meredith, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275823/
https://www.ncbi.nlm.nih.gov/pubmed/35819138
http://dx.doi.org/10.7554/eLife.77953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275823/
https://www.ncbi.nlm.nih.gov/pubmed/35819138
http://dx.doi.org/10.7554/eLife.77953

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