Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis

Astragaloside IV (AS-IV) is a bioactive saponin extracted from the Astragalus root and has been reported to exert a protective effect on diabetic nephropathy (DN). However, the underlying mechanism remains unclear. Herein, we found that AS-IV treatment alleviated DN symptoms in DN mice accompanied b...

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Detalles Bibliográficos
Autores principales: Fan, Yuyan, Fan, Hongyu, Li, Ping, Liu, Qingshan, Huang, Lixia, Zhou, Yilun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275872/
https://www.ncbi.nlm.nih.gov/pubmed/35510516
http://dx.doi.org/10.1080/21655979.2022.2068822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275872/
https://www.ncbi.nlm.nih.gov/pubmed/35510516
http://dx.doi.org/10.1080/21655979.2022.2068822

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