Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

INTRODUCTION: Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders. Although a majority of HDAC inhibitors use hydroxamic acids as zinc binding groups, hydroxamic acid zinc-binding groups suffer from poor bioavaila...

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Detalles Bibliográficos
Autores principales: Kim, Ji Hyun, Ali, Khan Hashim, Oh, Yong Jin, Seo, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
5700
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276175/
https://www.ncbi.nlm.nih.gov/pubmed/35512065
http://dx.doi.org/10.1097/MD.0000000000029049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276175/
https://www.ncbi.nlm.nih.gov/pubmed/35512065
http://dx.doi.org/10.1097/MD.0000000000029049

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