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Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group
INTRODUCTION: Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders. Although a majority of HDAC inhibitors use hydroxamic acids as zinc binding groups, hydroxamic acid zinc-binding groups suffer from poor bioavaila...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276175/ https://www.ncbi.nlm.nih.gov/pubmed/35512065 http://dx.doi.org/10.1097/MD.0000000000029049 |