The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana

The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana. The drugs are metabolized by Cytochrome P450 2B6 (CYP2B6) liver enzyme. The CYP2B6 gene t...

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Detalles Bibliográficos
Autores principales: Maseng, Monkgomotsi J., Tawe, Leabaneng, Thami, Prisca K., Moyo, Sikhulile, Kasvosve, Ishmael, Novitsky, Vladimir, Essex, Max, Russo, Gianluca, Gaseitsiwe, Simani, Paganotti, Giacomo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
4850
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276322/
https://www.ncbi.nlm.nih.gov/pubmed/35512066
http://dx.doi.org/10.1097/MD.0000000000029066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276322/
https://www.ncbi.nlm.nih.gov/pubmed/35512066
http://dx.doi.org/10.1097/MD.0000000000029066

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