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The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana

The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana. The drugs are metabolized by Cytochrome P450 2B6 (CYP2B6) liver enzyme. The CYP2B6 gene t...

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Detalles Bibliográficos
Autores principales:	Maseng, Monkgomotsi J., Tawe, Leabaneng, Thami, Prisca K., Moyo, Sikhulile, Kasvosve, Ishmael, Novitsky, Vladimir, Essex, Max, Russo, Gianluca, Gaseitsiwe, Simani, Paganotti, Giacomo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	4850
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276322/ https://www.ncbi.nlm.nih.gov/pubmed/35512066 http://dx.doi.org/10.1097/MD.0000000000029066

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