Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice

Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but essential for mosquito and liver stages. Despite having backup mechanisms to acquire hemoglobin-heme, pathway intermediates and/or enzymes from the host, asexual parasites express heme pathway enzymes and synthesize...

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Detalles Bibliográficos
Autores principales: Chandana, Manjunatha, Anand, Aditya, Ghosh, Sourav, Das, Rahul, Beura, Subhashree, Jena, Sarita, Suryawanshi, Amol Ratnakar, Padmanaban, Govindarajan, Nagaraj, Viswanathan Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276668/
https://www.ncbi.nlm.nih.gov/pubmed/35821013
http://dx.doi.org/10.1038/s41467-022-31431-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276668/
https://www.ncbi.nlm.nih.gov/pubmed/35821013
http://dx.doi.org/10.1038/s41467-022-31431-z

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