Base editing in human cells with monomeric DddA-TALE fusion deaminases

Inter-bacterial toxin DddA-derived cytosine base editors (DdCBEs) enable targeted C-to-T conversions in nuclear and organellar DNA. DddA(tox), the deaminase catalytic domain derived from Burkholderia cenocepacia, is split into two inactive halves to avoid its cytotoxicity in eukaryotic cells, when f...

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Detalles Bibliográficos
Autores principales: Mok, Young Geun, Lee, Ji Min, Chung, Eugene, Lee, Jaesuk, Lim, Kayeong, Cho, Sung-Ik, Kim, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276701/
https://www.ncbi.nlm.nih.gov/pubmed/35821233
http://dx.doi.org/10.1038/s41467-022-31745-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276701/
https://www.ncbi.nlm.nih.gov/pubmed/35821233
http://dx.doi.org/10.1038/s41467-022-31745-y

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