Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development

G protein coupled receptors (GPCRs) are a superfamily of transmembrane-spanning receptors that are activated by multiple endogenous ligands and are the most common target for agonist or antagonist therapeutics across a broad spectrum of diseases. Initial characterization within the superfamily sugge...

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Detalles Bibliográficos
Autores principales: Kim, Donghwa, Tokmakova, Alina, Woo, Jung-A A., An, Steven S., Goddard, William A., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276727/
https://www.ncbi.nlm.nih.gov/pubmed/35595932
http://dx.doi.org/10.1007/s40291-022-00592-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276727/
https://www.ncbi.nlm.nih.gov/pubmed/35595932
http://dx.doi.org/10.1007/s40291-022-00592-4

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