Cargando…

Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development

G protein coupled receptors (GPCRs) are a superfamily of transmembrane-spanning receptors that are activated by multiple endogenous ligands and are the most common target for agonist or antagonist therapeutics across a broad spectrum of diseases. Initial characterization within the superfamily sugge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Donghwa, Tokmakova, Alina, Woo, Jung-A A., An, Steven S., Goddard, William A., Liggett, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276727/ https://www.ncbi.nlm.nih.gov/pubmed/35595932 http://dx.doi.org/10.1007/s40291-022-00592-4

Ejemplares similares

Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease
por: Tokmakova, Alina, et al.
Publicado: (2022)

Identification and characterization of an atypical Gαs-biased β(2)AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis
por: Kim, Donghwa, et al.
Publicado: (2021)

Input–output maps are strongly biased towards simple outputs
por: Dingle, Kamaludin, et al.
Publicado: (2018)

Capturing Peptide–GPCR Interactions and Their Dynamics
por: Kaiser, Anette, et al.
Publicado: (2020)

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
por: Clark, Ashley J., et al.
Publicado: (2021)

Biophysical Detection of Diversity and Bias in GPCR Function
por: Jaeger, Werner C., et al.
Publicado: (2014)

Functional selectivity of GPCR-directed drug action through location bias
por: Irannejad, Roshanak, et al.
Publicado: (2017)

Is There a Role for GPCR Agonist Radiotracers in PET Neuroimaging?
por: Colom, Matthieu, et al.
Publicado: (2019)

Class B1 GPCR activation by an intracellular agonist
por: Kobayashi, Kazuhiro, et al.
Publicado: (2023)

Community guidelines for GPCR ligand bias: IUPHAR review 32
por: Kolb, Peter, et al.
Publicado: (2022)

Potential Utility of Biased GPCR Signaling for Treatment of Psychiatric Disorders
por: Komatsu, Hidetoshi, et al.
Publicado: (2019)

Location Bias as Emerging Paradigm in GPCR Biology and Drug Discovery
por: Mohammad Nezhady, Mohammad Ali, et al.
Publicado: (2020)

In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias
por: Morales-Pastor, Adrian, et al.
Publicado: (2022)

The mechanism for ligand activation of the GPCR–G protein complex
por: Mafi, Amirhossein, et al.
Publicado: (2022)

The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14
por: Kim, Donghwa, et al.
Publicado: (2021)

Computationally designed GPCR quaternary structures bias signaling pathway activation
por: Paradis, Justine S., et al.
Publicado: (2022)

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
por: Woo, Jung-AA, et al.
Publicado: (2021)

Capturing the complexity of sex differences requires multidimensional behavioral models
por: Siciliano, Cody A.
Publicado: (2019)

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
por: Mathiasen, Signe, et al.
Publicado: (2020)

Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins
por: Kamal, Maud, et al.
Publicado: (2011)

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation
por: Bruzzese, Agustín, et al.
Publicado: (2020)

β(2)-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function
por: Kim, Donghwa, et al.
Publicado: (2016)

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties
por: Panagiotopoulos, Athanasios A., et al.
Publicado: (2020)

A Multiplexed Fluorescent Calcium and NFAT Reporter Gene Assay to Identify GPCR Agonists
por: Sheth, Heeral, et al.
Publicado: (2013)

Progress Toward High Power Output in Thermionic Energy Converters
por: Campbell, Matthew F., et al.
Publicado: (2021)

Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
por: Butler, Rebecca A., et al.
Publicado: (2014)

Location bias contributes to functionally selective responses of biased CXCR3 agonists
por: Eiger, Dylan Scott, et al.
Publicado: (2022)

Novel approaches leading towards peptide GPCR de‐orphanisation
por: Hauser, Alexander S., et al.
Publicado: (2020)

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state
por: Cao, Anne-Marinette, et al.
Publicado: (2021)

Editorial: Capturing Biological Complexity and Heterogeneity Using Multidimensional MRI
por: Bouhrara, Mustapha, et al.
Publicado: (2022)

A Web Server for GPCR-GPCR Interaction Pair Prediction
por: Nemoto, Wataru, et al.
Publicado: (2022)

G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias
por: Chen, Qiuyan, et al.
Publicado: (2022)

Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6
por: Wilde, Caroline, et al.
Publicado: (2023)

An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement
por: Killoran, Michael P., et al.
Publicado: (2021)

GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A(2A) Adenosine Receptor
por: Shiriaeva, Anna, et al.
Publicado: (2022)

Variable G protein determinants of GPCR coupling selectivity
por: Okashah, Najeah, et al.
Publicado: (2019)

Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation
por: Lebon, Guillaume, et al.
Publicado: (2011)

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
por: Miles, Timothy F, et al.
Publicado: (2018)

Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery
por: Tsou, Lun K., et al.
Publicado: (2020)

BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations
por: El Khamlichi, Chayma, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dlvqhg8fjfc0ga0qn2rcqet7c1