Cargando…

Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice

N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in neurodegenerative disorders remains unknown. Here we investigated the m6A methylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pupak, Anika, Singh, Ankita, Sancho-Balsells, Anna, Alcalá-Vida, Rafael, Espina, Marc, Giralt, Albert, Martí, Eulàlia, Ørom, Ulf Andersson Vang, Ginés, Silvia, Brito, Verónica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276730/ https://www.ncbi.nlm.nih.gov/pubmed/35819730 http://dx.doi.org/10.1007/s00018-022-04444-6

Ejemplares similares

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model
por: Giralt, Albert, et al.
Publicado: (2017)

Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
por: Rodríguez-Urgellés, Ened, et al.
Publicado: (2023)

Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons
por: Sancho-Balsells, Anna, et al.
Publicado: (2023)

Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease
por: Saavedra, Ana, et al.
Publicado: (2013)

p75(NTR) in Huntington's disease: beyond the basal ganglia
por: Brito, Verónica, et al.
Publicado: (2015)

Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes
por: Montalban, Enrica, et al.
Publicado: (2019)

Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease
por: Ransome, Mark I., et al.
Publicado: (2012)

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies
por: Brito, V, et al.
Publicado: (2013)

Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1
por: Sancho-Balsells, Anna, et al.
Publicado: (2020)

RTP801/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington’s Disease
por: Pérez-Sisqués, Leticia, et al.
Publicado: (2021)

Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
por: Rodríguez-Urgellés, Ened, et al.
Publicado: (2022)

Awareness of Memory Deficits in Early Stage Huntington's Disease
por: Cleret de Langavant, Laurent, et al.
Publicado: (2013)

Long ncRNA A-ROD activates its target gene DKK1 at its release from chromatin
por: Ntini, Evgenia, et al.
Publicado: (2018)

Insight into miRNA biogenesis with RNA sequencing
por: Conrad, Thomas, et al.
Publicado: (2015)

Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington Disease
por: Kolodziejczyk, Karolina, et al.
Publicado: (2014)

The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease
por: Quirion, Jade G., et al.
Publicado: (2019)

Sleep deficits but no metabolic deficits in premanifest Huntington's disease
por: Lazar, Alpar S., et al.
Publicado: (2015)

Counterfactual Thinking Deficit in Huntington’s Disease
por: Solca, Federica, et al.
Publicado: (2015)

Behavioral Deficits in Juvenile Onset Huntington’s Disease
por: Langbehn, Kathleen E., et al.
Publicado: (2020)

CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
por: Comella Bolla, Andrea, et al.
Publicado: (2019)

Placental transfer of NMDAR antibodies causes reversible alterations in mice
por: García-Serra, Anna, et al.
Publicado: (2020)

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice
por: Suelves, Nuria, et al.
Publicado: (2017)

Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs
por: Louloupi, Annita, et al.
Publicado: (2017)

Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
por: Dargaei, Zahra, et al.
Publicado: (2018)

Dissociable Motivational Deficits in Pre-manifest Huntington’s Disease
por: Atkins, Kelly J., et al.
Publicado: (2020)

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
por: Zhang, Hongyu, et al.
Publicado: (2018)

The search for early markers of AD: hippocampal atrophy and memory deficits
por: Barnes, Josephine, et al.
Publicado: (2014)

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy
por: Postma, Tjardo S., et al.
Publicado: (2020)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons
por: López-Molina, Laura, et al.
Publicado: (2022)

Serial interactome capture of the human cell nucleus
por: Conrad, Thomas, et al.
Publicado: (2016)

Meridianins Inhibit GSK3β In Vivo and Improve Behavioral Alterations Induced by Chronic Stress
por: Sancho-Balsells, Anna, et al.
Publicado: (2022)

RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory
por: Sinkevicius, Kerstin W., et al.
Publicado: (2018)

Long ncRNA expression associates with tissue-specific enhancers
por: Vučićević, Dubravka, et al.
Publicado: (2015)

A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity
por: Bañez-Coronel, Mónica, et al.
Publicado: (2012)

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy
por: Fernández-García, Sara, et al.
Publicado: (2020)

The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit
por: Nasehi, Mohammad
Publicado: (2015)

Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit
por: Prada Jardim, Anaclara, et al.
Publicado: (2017)

Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
por: Woo, Hanwoong, et al.
Publicado: (2018)

Hippocampal Network Oscillations Rescue Memory Consolidation Deficits Caused by Sleep Loss
por: Ognjanovski, Nicolette, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_95rk6eulbuio6ja25ook5lmi4g