Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes

Characterizing the effect of mutations is key to understand the evolution of protein sequences and to separate neutral amino-acid changes from deleterious ones. Epistatic interactions between residues can lead to a context dependence of mutation effects. Context dependence constrains the amino-acid...

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Detalles Bibliográficos
Autores principales: Vigué, Lucile, Croce, Giancarlo, Petitjean, Marie, Ruppé, Etienne, Tenaillon, Olivier, Weigt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276797/
https://www.ncbi.nlm.nih.gov/pubmed/35821377
http://dx.doi.org/10.1038/s41467-022-31643-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276797/
https://www.ncbi.nlm.nih.gov/pubmed/35821377
http://dx.doi.org/10.1038/s41467-022-31643-3

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