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Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes
Characterizing the effect of mutations is key to understand the evolution of protein sequences and to separate neutral amino-acid changes from deleterious ones. Epistatic interactions between residues can lead to a context dependence of mutation effects. Context dependence constrains the amino-acid...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276797/ https://www.ncbi.nlm.nih.gov/pubmed/35821377 http://dx.doi.org/10.1038/s41467-022-31643-3 |