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Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma

The tyrosine kinase inhibitor lenvatinib is used to treat advanced hepatocellular carcinoma (HCC). Ferroptosis is a type of cell death characterized by the iron‐dependent accumulation of lethal lipid reactive oxygen species (ROS). Nuclear factor erythroid‐derived 2‐like 2 (Nrf2) protects HCC cells a...

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Detalles Bibliográficos
Autores principales: Iseda, Norifumi, Itoh, Shinji, Toshida, Katsuya, Tomiyama, Takahiro, Morinaga, Akinari, Shimokawa, Masahiro, Shimagaki, Tomonari, Wang, Huanlin, Kurihara, Takeshi, Toshima, Takeo, Nagao, Yoshihiro, Harada, Noboru, Yoshizumi, Tomoharu, Mori, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277415/
https://www.ncbi.nlm.nih.gov/pubmed/35466502
http://dx.doi.org/10.1111/cas.15378