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Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation
To investigate the effect of Flammulina velutipes polysaccharides (FVPs) on mice intestinal inflammation, FVPs were extracted from Flammulina velutipes (FV) using a solid anaerobic fermentation technique. The antioxidant and anti-inflammatory capacities of FVP and fermented FVP (FFVP) induced by lip...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277576/ https://www.ncbi.nlm.nih.gov/pubmed/35845765 http://dx.doi.org/10.3389/fnut.2022.934073 |
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author | Ma, Sheng Xu, Jianxiong Lai, Ting Xu, Weina Zhang, Jing Zhang, Hongcai Zhang, Weiyi |
author_facet | Ma, Sheng Xu, Jianxiong Lai, Ting Xu, Weina Zhang, Jing Zhang, Hongcai Zhang, Weiyi |
author_sort | Ma, Sheng |
collection | PubMed |
description | To investigate the effect of Flammulina velutipes polysaccharides (FVPs) on mice intestinal inflammation, FVPs were extracted from Flammulina velutipes (FV) using a solid anaerobic fermentation technique. The antioxidant and anti-inflammatory capacities of FVP and fermented FVP (FFVP) induced by lipopolysaccharide (LPS) were investigated in vitro and in vivo. The results showed that the yield of FFVP (9.44%) was higher than that of FVP (8.65%), but the molecular weight (MW) of FFVP (15,702 Da) was lower than that of FVP (15,961 Da). The antioxidant and anti-inflammatory capacities of FFVP were higher than that of FVP in preventing mice diarrhea, enhancing antioxidant capacities, and reducing the secretion and mRNA expression of interleukin-1β (IL-1β), IL-6, IL-18, and tumor necrosis factor-α (TNF-α). The anti-inflammatory mechanisms of FVP and FFVP were analyzed by inhibiting the activation of the NLRP3 signaling pathway using an LPS-induced mice model. This study indicated that FFVP could be used as a functional antioxidant, indicating a potential application in functional food and health products. |
format | Online Article Text |
id | pubmed-9277576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92775762022-07-14 Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation Ma, Sheng Xu, Jianxiong Lai, Ting Xu, Weina Zhang, Jing Zhang, Hongcai Zhang, Weiyi Front Nutr Nutrition To investigate the effect of Flammulina velutipes polysaccharides (FVPs) on mice intestinal inflammation, FVPs were extracted from Flammulina velutipes (FV) using a solid anaerobic fermentation technique. The antioxidant and anti-inflammatory capacities of FVP and fermented FVP (FFVP) induced by lipopolysaccharide (LPS) were investigated in vitro and in vivo. The results showed that the yield of FFVP (9.44%) was higher than that of FVP (8.65%), but the molecular weight (MW) of FFVP (15,702 Da) was lower than that of FVP (15,961 Da). The antioxidant and anti-inflammatory capacities of FFVP were higher than that of FVP in preventing mice diarrhea, enhancing antioxidant capacities, and reducing the secretion and mRNA expression of interleukin-1β (IL-1β), IL-6, IL-18, and tumor necrosis factor-α (TNF-α). The anti-inflammatory mechanisms of FVP and FFVP were analyzed by inhibiting the activation of the NLRP3 signaling pathway using an LPS-induced mice model. This study indicated that FFVP could be used as a functional antioxidant, indicating a potential application in functional food and health products. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9277576/ /pubmed/35845765 http://dx.doi.org/10.3389/fnut.2022.934073 Text en Copyright © 2022 Ma, Xu, Lai, Xu, Zhang, Zhang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Ma, Sheng Xu, Jianxiong Lai, Ting Xu, Weina Zhang, Jing Zhang, Hongcai Zhang, Weiyi Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title | Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title_full | Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title_fullStr | Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title_full_unstemmed | Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title_short | Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation |
title_sort | inhibitory effect of fermented flammulina velutipes polysaccharides on mice intestinal inflammation |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277576/ https://www.ncbi.nlm.nih.gov/pubmed/35845765 http://dx.doi.org/10.3389/fnut.2022.934073 |
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