Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal

Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug–drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/rito...

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Autores principales: Rose, Dusten T, Gandhi, Saurin M, Bedard, Rachael A, Mondy, Kristin E, Chu, Alexander L, Gamble, Kelly C, Gee, Amanda T, Kundra, Monica A, Williams, Amber L, Lee, Brian K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Novel Id Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277654/
https://www.ncbi.nlm.nih.gov/pubmed/35854994
http://dx.doi.org/10.1093/ofid/ofac238
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author Rose, Dusten T
Gandhi, Saurin M
Bedard, Rachael A
Mondy, Kristin E
Chu, Alexander L
Gamble, Kelly C
Gee, Amanda T
Kundra, Monica A
Williams, Amber L
Lee, Brian K
author_facet Rose, Dusten T
Gandhi, Saurin M
Bedard, Rachael A
Mondy, Kristin E
Chu, Alexander L
Gamble, Kelly C
Gee, Amanda T
Kundra, Monica A
Williams, Amber L
Lee, Brian K
author_sort Rose, Dusten T
collection PubMed
description Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug–drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/ritonavir for outpatient use who developed tacrolimus toxicity requiring hospitalization and were managed with rifampin for toxicity reversal.
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spelling pubmed-92776542022-07-18 Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal Rose, Dusten T Gandhi, Saurin M Bedard, Rachael A Mondy, Kristin E Chu, Alexander L Gamble, Kelly C Gee, Amanda T Kundra, Monica A Williams, Amber L Lee, Brian K Open Forum Infect Dis Novel Id Cases Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug–drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/ritonavir for outpatient use who developed tacrolimus toxicity requiring hospitalization and were managed with rifampin for toxicity reversal. Oxford University Press 2022-05-13 /pmc/articles/PMC9277654/ /pubmed/35854994 http://dx.doi.org/10.1093/ofid/ofac238 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel Id Cases
Rose, Dusten T
Gandhi, Saurin M
Bedard, Rachael A
Mondy, Kristin E
Chu, Alexander L
Gamble, Kelly C
Gee, Amanda T
Kundra, Monica A
Williams, Amber L
Lee, Brian K
Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title_full Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title_fullStr Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title_full_unstemmed Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title_short Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal
title_sort supratherapeutic tacrolimus concentrations with nirmatrelvir/ritonavir in solid organ transplant recipients requiring hospitalization: a case series using rifampin for reversal
topic Novel Id Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277654/
https://www.ncbi.nlm.nih.gov/pubmed/35854994
http://dx.doi.org/10.1093/ofid/ofac238
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