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Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis

BACKGROUND: Traumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood–brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has been demonstrated to be critical in limiting the increase in BBB vesicle trans...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Wang, Lin, Pan, Qiuling, Yang, Xiaomin, Cao, Yunchuan, Yan, Jin, Wang, Yingwen, Tao, Yihao, Fan, Runjin, Sun, Xiaochuan, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277863/
https://www.ncbi.nlm.nih.gov/pubmed/35820896
http://dx.doi.org/10.1186/s12987-022-00356-6