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An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)
Conventional drug development strategies typically use pocket in protein structures as drug-target sites. They overlook the plausible effects of protein evolvability and resistant mutations on protein structure which in turn may impair protein-drug interaction. In this study, we used an integrated e...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier B.V.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278002/ https://www.ncbi.nlm.nih.gov/pubmed/35841961 http://dx.doi.org/10.1016/j.ijbiomac.2022.07.022 |