Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

Optimizing linker design is important for ensuring efficient degradation activity of proteolysis‐targeting chimeras (PROTACs). Therefore, developing a straightforward synthetic approach that combines the protein‐of‐interest ligand (POI ligand) and the ligand for E3 ubiquitin ligase (E3 ligand) in va...

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Detalles Bibliográficos
Autores principales: Xu, Hanqiao, Kurohara, Takashi, Takano, Reina, Yokoo, Hidetomo, Shibata, Norihito, Ohoka, Nobumichi, Inoue, Takao, Naito, Mikihiko, Demizu, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278092/
https://www.ncbi.nlm.nih.gov/pubmed/35822913
http://dx.doi.org/10.1002/open.202200131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278092/
https://www.ncbi.nlm.nih.gov/pubmed/35822913
http://dx.doi.org/10.1002/open.202200131

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