Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds

Fibrin polymerization involves thrombin-mediated exposure of knobs on one monomer that bind to holes available on another, leading to the formation of fibers. In silico evidence has suggested that the classical A:a knob-hole interaction is enhanced by surrounding residues not directly involved in th...

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Detalles Bibliográficos
Autores principales: Asquith, Nathan L., Duval, Cédric, Zhmurov, Artem, Baker, Stephen R., McPherson, Helen R., Domingues, Marco M., Connell, Simon D. A., Barsegov, Valeri, Ariëns, Robert A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278297/
https://www.ncbi.nlm.nih.gov/pubmed/35561308
http://dx.doi.org/10.1182/bloodadvances.2022006977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278297/
https://www.ncbi.nlm.nih.gov/pubmed/35561308
http://dx.doi.org/10.1182/bloodadvances.2022006977

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