Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid decay. The nuclear exosome targeting (NEXT) complex plays a central role in directing non-functional transcripts to exosome-mediated degradati...

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Detalles Bibliográficos
Autores principales: Gerlach, Piotr, Garland, William, Lingaraju, Mahesh, Salerno-Kochan, Anna, Bonneau, Fabien, Basquin, Jérôme, Jensen, Torben Heick, Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278407/
https://www.ncbi.nlm.nih.gov/pubmed/35688157
http://dx.doi.org/10.1016/j.molcel.2022.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278407/
https://www.ncbi.nlm.nih.gov/pubmed/35688157
http://dx.doi.org/10.1016/j.molcel.2022.04.011

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