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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid decay. The nuclear exosome targeting (NEXT) complex plays a central role in directing non-functional transcripts to exosome-mediated degradati...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278407/ https://www.ncbi.nlm.nih.gov/pubmed/35688157 http://dx.doi.org/10.1016/j.molcel.2022.04.011 |