Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via CDK2 inhibition. In this research, new series of pyrazolopyrimidine derivativ...

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Detalles Bibliográficos
Autores principales: Mandour, Asmaa A., Nassar, Ibrahim F., Abdel Aal, Mohammed T., Shahin, Mahmoud A. E., El-Sayed, Wael A., Hegazy, Maghawry, Yehia, Amr Mohamed, Ismail, Ahmed, Hagras, Mohamed, Elkaeed, Eslam B., Refaat, Hanan M., Ismail, Nasser S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278437/
https://www.ncbi.nlm.nih.gov/pubmed/35815597
http://dx.doi.org/10.1080/14756366.2022.2086866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278437/
https://www.ncbi.nlm.nih.gov/pubmed/35815597
http://dx.doi.org/10.1080/14756366.2022.2086866

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