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Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via CDK2 inhibition. In this research, new series of pyrazolopyrimidine derivativ...
Autores principales: | Mandour, Asmaa A., Nassar, Ibrahim F., Abdel Aal, Mohammed T., Shahin, Mahmoud A. E., El-Sayed, Wael A., Hegazy, Maghawry, Yehia, Amr Mohamed, Ismail, Ahmed, Hagras, Mohamed, Elkaeed, Eslam B., Refaat, Hanan M., Ismail, Nasser S. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278437/ https://www.ncbi.nlm.nih.gov/pubmed/35815597 http://dx.doi.org/10.1080/14756366.2022.2086866 |
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