Cargando…

Investigating Celastrol's Anti-DCM Targets and Mechanisms via Network Pharmacology and Experimental Validation

METHODS: Data from TCMSP and GEO databases were utilized to identify targets for Celastrol on DCM. The relationship between the major targets and conventional glycolipid metabolism was obtained with Spearman correlation analysis. Experiments on animals were conducted utilizing healthy control (HC),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xi, Rui, Wan, Yongxin, Yang, Lihong, Zhang, Jingying, Yang, Liu, Yang, Shuai, Chai, Rui, Mu, Fengchen, Sun, Qiting, Yan, Rui, Wu, Zhifang, Li, Sijin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278495/ https://www.ncbi.nlm.nih.gov/pubmed/35845929 http://dx.doi.org/10.1155/2022/7382130

Ejemplares similares

Autophagy in the pharmacological activities of celastrol (Review)
por: Zhang, Caixia, et al.
Publicado: (2023)

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis
por: Xie, Wendong, et al.
Publicado: (2023)

Network discovery with DCM
por: Friston, Karl J., et al.
Publicado: (2011)

The DCM Project Portal: A direct-to-participant platform of The DCM Research Project
por: Jordan, Elizabeth S., et al.
Publicado: (2023)

An electrophysiological validation of stochastic DCM for fMRI
por: Daunizeau, J., et al.
Publicado: (2013)

Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy
por: Zhao, Juanyong, et al.
Publicado: (2023)

Correlation Between Arrhythmia and the Prognosis in Children With EFE/LVNC/DCM
por: Wang, Hong, et al.
Publicado: (2020)

Exploration of the effect of Celastrol on protein targets in nasopharyngeal carcinoma: Network pharmacology, molecular docking and experimental evaluations
por: Ling, Junjun, et al.
Publicado: (2022)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents
por: Zhang, Hong-Jian, et al.
Publicado: (2017)

Comparing hemodynamic models with DCM
por: Stephan, Klaas Enno, et al.
Publicado: (2007)

Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib
por: Zhang, Rui, et al.
Publicado: (2019)

Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification
por: Wu, Huihuan, et al.
Publicado: (2022)

Effects and mechanisms of Celastrol on the formation of neutrophil extracellular traps (NETs)
por: Song, Rui, et al.
Publicado: (2023)

Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model
por: Yang, Hongbin, et al.
Publicado: (2017)

The Role of AI in Characterizing the DCM Phenotype
por: Asher, Clint, et al.
Publicado: (2021)

Effect of celastrol on bone structure and mechanics in arthritic rats
por: Cascão, Rita, et al.
Publicado: (2017)

Construct validation of a DCM for resting state fMRI
por: Razi, Adeel, et al.
Publicado: (2015)

Identifying the Effect of Celastrol Against Ovarian Cancer With Network Pharmacology and In Vitro Experiments
por: Wang, Xuan, et al.
Publicado: (2022)

A DCM for resting state fMRI
por: Friston, Karl J., et al.
Publicado: (2014)

The functional anatomy of attention: a DCM study
por: Brown, Harriet R., et al.
Publicado: (2013)

The D.C.M. for Field Ambulance Men
Publicado: (1915)

Research activity amongst DCM research priorities
por: Grodzinski, Ben, et al.
Publicado: (2021)

Development and validation of the discomfort of cloth Masks-12 (DCM-12) scale
por: Mumma, Joel M., et al.
Publicado: (2022)

Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM
por: Butler, Max B., et al.
Publicado: (2020)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

The mechanisms of celastrol in treating papillary thyroid carcinoma based on network pharmacology and experiment verification
por: Yi, Jiaoyu, et al.
Publicado: (2021)

Distinct Mechanism of Audiovisual Integration With Informative and Uninformative Sound in a Visual Detection Task: A DCM Study
por: Li, Qi, et al.
Publicado: (2019)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

Benefits of Using the DCM4CHE DICOM Archive
por: Warnock, Max J., et al.
Publicado: (2007)

Dcm methylation is detrimental to plasmid transformation in Clostridium thermocellum
por: Guss, Adam M, et al.
Publicado: (2012)

Empirical Bayes for DCM: A Group Inversion Scheme
por: Friston, Karl, et al.
Publicado: (2015)

Editorial: Understanding Molecular Mechanisms in Diabetic Cardiomyopathy (DCM)
por: Muthu, Sakthijothi, et al.
Publicado: (2022)

Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation
por: Zuo, Ximeng, et al.
Publicado: (2022)

Celastrol-based nanomedicine promotes corneal allograft survival
por: Li, Zhanrong, et al.
Publicado: (2021)

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice
por: Li, Mingyue, et al.
Publicado: (2022)

Celastrol Self-Stabilized Nanoparticles for Effective Treatment of Melanoma
por: Li, Jinran, et al.
Publicado: (2020)

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
por: Yang, Guangxia, et al.
Publicado: (2022)

Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss
por: Yang, Yi-Fang, et al.
Publicado: (2022)

The genome of Tripterygium wilfordii and characterization of the celastrol biosynthesis pathway
por: Pei, Tianlin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ieasrj47a56h3evad0d0epr9s5