Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma that contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role within the PDAC tumor micro...

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Detalles Bibliográficos
Autores principales: Garcia Garcia, Carolina J., Huang, Yanqing, Fuentes, Natividad R., Turner, Madeleine C., Monberg, Maria E., Lin, Daniel, Nguyen, Nicholas D., Fujimoto, Tara N., Zhao, Jun, Lee, Jaewon J., Bernard, Vincent, Yu, Meifang, Delahoussaye, Abagail M., Sacarello, Iancarlos Jimenez, Caggiano, Emily G., Phan, Jae L., Deorukhkar, Amit, Molkentine, Jessica M., Saur, Dieter, Maitra, Anirban, Taniguchi, Cullen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278556/
https://www.ncbi.nlm.nih.gov/pubmed/35216965
http://dx.doi.org/10.1053/j.gastro.2022.02.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278556/
https://www.ncbi.nlm.nih.gov/pubmed/35216965
http://dx.doi.org/10.1053/j.gastro.2022.02.024

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